GRID1

Protein-coding gene in the species Homo sapiens
GRID1
Identifiers
AliasesGRID1, GluD1, glutamate ionotropic receptor delta type subunit 1, GluD1-b
External IDsOMIM: 610659; MGI: 95812; HomoloGene: 69017; GeneCards: GRID1; OMA:GRID1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for GRID1
Genomic location for GRID1
Band10q23.1-q23.2Start85,599,552 bp[1]
End86,366,795 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for GRID1
Genomic location for GRID1
Band14 B|14 20.84 cMStart34,542,065 bp[2]
End35,305,336 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • C1 segment

  • nucleus accumbens

  • putamen

  • caudate nucleus

  • hypothalamus

  • substantia nigra

  • external globus pallidus

  • Pars compacta

  • amygdala
Top expressed in
  • Region I of hippocampus proper

  • dentate gyrus of hippocampal formation granule cell

  • nucleus accumbens

  • dorsomedial hypothalamic nucleus

  • perirhinal cortex

  • entorhinal cortex

  • superior frontal gyrus

  • primary visual cortex

  • lumbar subsegment of spinal cord

  • substantia nigra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ion channel activity
  • extracellularly glutamate-gated ion channel activity
  • ionotropic glutamate receptor activity
  • glutamate receptor activity
  • signaling receptor activity
  • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Cellular component
  • integral component of membrane
  • cell junction
  • postsynaptic membrane
  • plasma membrane
  • synapse
  • extracellular exosome
  • membrane
  • glutamatergic synapse
  • integral component of postsynaptic density membrane
Biological process
  • social behavior
  • ion transmembrane transport
  • ionotropic glutamate receptor signaling pathway
  • ion transport
  • excitatory postsynaptic potential
  • transport
  • synaptic transmission, glutamatergic
  • modulation of chemical synaptic transmission
  • regulation of postsynaptic membrane potential
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2894

14803

Ensembl

ENSG00000182771

ENSMUSG00000041078

UniProt

Q9ULK0

Q61627

RefSeq (mRNA)

NM_017551

NM_008166

RefSeq (protein)

NP_060021

NP_032192

Location (UCSC)Chr 10: 85.6 – 86.37 MbChr 14: 34.54 – 35.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein[5][6] (1009 aa) encoded by the GRID1 gene.[7][8] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[9]

Function

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system[10] and is important in synaptic plasticity.[7][11]

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[12][13]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182771 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041078 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochemical and Biophysical Research Communications. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID 1372507.
  6. ^ Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics. 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID 9828146.
  7. ^ a b "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1".
  8. ^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
  9. ^ Herbrechter R, Hube N, Buchholz R, Reiner A (June 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. PMC 8257547. PMID 34100982.
  10. ^ Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, et al. (April 2020). "Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain". The Journal of Comparative Neurology. 528 (6): 1003–1027. doi:10.1002/cne.24792. PMID 31625608. S2CID 203937925.
  11. ^ Yuzaki M, Aricescu AR (March 2017). "A GluD Coming-Of-Age Story". Trends in Neurosciences. 40 (3): 138–150. doi:10.1016/j.tins.2016.12.004. PMC 5553105. PMID 28110935.
  12. ^ Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, et al. (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophrenia Research. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID 17490860. S2CID 9497500.
  13. ^ Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, et al. (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophrenia Research. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID 19346103. S2CID 20949145.

Further reading

  • Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, et al. (December 2005). "Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios". American Journal of Human Genetics. 77 (6): 918–36. doi:10.1086/497703. PMC 1285177. PMID 16380905.
  • Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N (August 2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. doi:10.1016/S0896-6273(02)00861-9. PMID 12372286. S2CID 10534933.
  • Ly CD, Roche KW, Lee HK, Wenthold RJ (February 2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochemical and Biophysical Research Communications. 291 (1): 85–90. doi:10.1006/bbrc.2002.6413. PMID 11829466.
  • Roche KW, Ly CD, Petralia RS, Wang YX, McGee AW, Bredt DS, Wenthold RJ (May 1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses". The Journal of Neuroscience. 19 (10): 3926–34. doi:10.1523/JNEUROSCI.19-10-03926.1999. PMC 6782719. PMID 10234023.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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