| FMO4 |
|---|
|
| Identifikatori |
|---|
| Alijasi | FMO4 |
|---|
| Spoljašnji ID | OMIM: 136131 MGI: 2429497 HomoloGene: 68219 GeneCards: FMO4 |
|---|
| Genska lokacija (miš) |
|---|
 | | Hr. | Chromosome 1 (mouse)[1] |
|---|
| | Band | 1 H2.1|1 70.34 cM | Start | 162,620,757 bp[1] |
|---|
| Kraj | 162,641,541 bp[1] |
|---|
|
| Obrazac RNK izražavanja |
|---|
 | | More reference expression data |
|
| Ortolozi |
|---|
| Vrste | Čovek | Miš |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | | |
|---|
| RefSeq (protein) | | |
|---|
| Location (UCSC) | n/a | Chr 1: 162.62 – 162.64 Mb |
|---|
| PubMed search | [2] | [3] |
|---|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Dimetilanilin monooksigenaza (N-oksid-formirajuća) 4 je enzim koji je kod ljudi kodiran FMO4 genom.[4][5]
Funkcija
Metabolička N-oksidacija amino-trimetilamina (TMA) iz hrane je posredovana monooksigenazom koja sadrži flavin. Ovaj gen ispoljava nasledni FMO3 polimorfizam kod ljudi koji rezultira u maloj potpopulaciji sa umanjenom TMA N-oksidacionom sposobnošću, posledica čega je sindrom zadaha ribe, trimetilaminurija. Tri forme ovog enzima, FMO1 u fetalnoj jetri, FMO2 u jetri odraslih osoba, i FMO3 su kodirani genima koji su grupisani u 1q23-q25 regionu. Monooksigenze koje sadrže flavin su NADPH zavisni flavoenzimi koji katalizuju oksidaciju nukleofilnih heteroatomskih centera ksenobiotika kao što su pesticidi i lekovi.[5]
Vidi još
- Dimetilanilin monooksigenaza (formiranje N-oksida)
Reference
- ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000026692 - Ensembl, May 2017
- ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lawton MP, Cashman JR, Cresteil T, Dolphin CT, Elfarra AA, Hines RN, Hodgson E, Kimura T, Ozols J, Phillips IR (1994). „A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities”. Arch Biochem Biophys. 308 (1): 254—7. PMID 8311461. doi:10.1006/abbi.1994.1035.
- ^ а б „Entrez Gene: FMO4 flavin containing monooxygenase 4”.
Literatura
- Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM (1994). „The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression”. Toxicol. Appl. Pharmacol. 125 (1): 1—6. PMID 8128486. doi:10.1006/taap.1994.1042.
- Dolphin CT, Shephard EA, Povey S, Smith RL, Phillips IR (1992). „Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family”. Biochem. J. 287 ( Pt 1) (Pt 1): 261—7. PMC 1133153
. PMID 1417778. - Phillips IR, Dolphin CT, Clair P, Hadley MR, Hutt AJ, McCombie RR, Smith RL, Shephard EA (1995). „The molecular biology of the flavin-containing monooxygenases of man”. Chem. Biol. Interact. 96 (1): 17—32. PMID 7720101. doi:10.1016/0009-2797(94)03580-2.
- Itagaki K, Carver GT, Philpot RM (1996). „Expression and characterization of a modified flavin-containing monooxygenase 4 from humans”. J. Biol. Chem. 271 (33): 20102—7. PMID 8702731. doi:10.1074/jbc.271.33.20102.
- Janmohamed A, Dolphin CT, Phillips IR, Shephard EA (2001). „Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450”. Biochem. Pharmacol. 62 (6): 777—86. PMID 11551524. doi:10.1016/S0006-2952(01)00718-3.
- Furnes B, Feng J, Sommer SS, Schlenk D (2003). „Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans”. Drug Metab. Dispos. 31 (2): 187—93. PMID 12527699. doi:10.1124/dmd.31.2.187.
|
|---|
| Teme | |
|---|
| Tipovi | |
|---|
- B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
|
